Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids
نویسندگان
چکیده
منابع مشابه
Microwave-assisted Cu-catalyzed protodecarboxylation of aromatic carboxylic acids.
An effective protocol has been developed that allows the smooth protodecarboxylation of diversely functionalized aromatic carboxylic acids within 5-15 min. In the presence of at most 5 mol % of an inexpensive catalyst generated in situ from copper(I) oxide and 1,10-phenanthroline, even nonactivated benzoates were converted in high yields and with great preparative ease.
متن کاملSilver-catalysed protodecarboxylation of carboxylic acids.
A silver-based catalyst system has been discovered that effectively promotes the protodecarboxylation of various carboxylic acids at temperatures of 80-120 degrees C--more than 50 degrees C below those of the best known copper catalysts.
متن کاملProtodecarboxylation of benzoic acids under radical conditions.
A new approach to protodecarboxylation is described that enhances the substrate scope for benzoic acids. The reaction uses oxidative radical conditions to decarboxylate a variety of acids in acetonitrile.
متن کاملPalladium-catalyzed 2,2,2-trifluoroethylation of organoboronic acids and esters.
The introduction of a fluorinated moiety into organic molecules can result in profound changes of the biological activities of these molecules, and therefore, this strategy has been widely used in drug design. Among various fluorinated moieties, the trifluoromethyl group (CF3) has been the focus of increasing attention owing to its capacity to act as a lipophilic electron-withdrawing group. In ...
متن کاملPalladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion.
A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. In addition, by applying this protocol as the key step, indenopyrazole derivatives can be easily synthesized in high yields in a one-pot procedure. This methodology is tolerant of a wide range of substrates and applic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic Letters
سال: 2018
ISSN: 1523-7060,1523-7052
DOI: 10.1021/acs.orglett.8b03016